Miracon Science

thiazides

Mechanism of interaction

Mechanism of interaction
Magnesium
Potassium		 The renal loss of magnesium and potassium is increased by thiazides. The loss of magnesium is to be considered more critical, as this leads to a potassium deficiency
Folic acid
Vitamin B6
Vitamin B12		 The excretion of folic acid, vitamin B6 and vitamin B12 is increased by taking thiazide. Homocysteine level also rises.
Zinc The amount of zinc excreted by the urine is increased by taking thiazide.

 

Consequences and possible symptoms of the interaction

Negative consequences of the interaction Possible symptoms
Magnesium
Potassium		 Decrease in magnesium and potassium levels
  • Hypokalemia
  • Hypomagnesemia
  • Calf cramps at night
  • Constipation
  • Disorder in lipid metabolism
  • Disorder of glucose tolerance
  • Arrythmias 
Folic acid
Vitamin B6
Vitamin B12		 Decrease in folic acid, vitamin B6- and vitamin B12 levels
  • Hyperhomocysteinemia
Zinc Decrease of the zinc level
  • Wound healing disorders, hair loss, brittle, white spotted nails
  • Increased susceptibility to infections
  • Concentration disorders, hyperactivity, depression

 

Recommended Supplementation

Pharmaceutical substance Recommended supplementation Dosage
Thiazide Magnesium 400-1200 mg/d p.o.
Folic acid 0.4-1 mg/d p.o.
Zinc 20 mg/d p.o.

Special instructions for use

Recommended supplementation
Folic acid Always combine with vitamin B6 and vitamin B12.

References

References
Gröber Uwe: Mikronährstoffe. Metabolic Tuning – Prävention – Therapie. 3. Auflage, 2011
Gröber Uwe: Arzneimittel und Mikronährstoffe. Medikationsorientierte Supplementierung. 3. akt. und erw. Auflage, 2014
Iezhitsa IN. Potassium and magnesium depletions in congestive heart failure--pathophysiology, consequences and replenishment. Clin Calcium. 2005 Nov;15(11):123-33.
Stargrove Mitchell Bebel, Treasure Jonathan, McKee Dwight L.: Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. 2008
Wester PO. Urinary zinc excretion during treatment with different diuretics. Acta Med Scand. 1980;208(3):209-12.
Westphal S et al. Antihypertensive treatment and homocysteine concentrations. Metabolism. 2003 Mar;52(3):261-3.

 

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