Psyllium

Synonym(s): arabinose, galacturonic acid, plantago ovata, psyllium, ramnose, xylose
Nutrient group: Probiotics & Fibers

Detailed information

Psyllium has high water binding capacity
Psyllium is obtained from the shells or husks of Plantago ovata. The mucilages contained in psyllium seeds, primarily galacturonic acid, xylose, ramnose and arabinose, have a high water-binding capacity. Psyllium can increase its volume by a factor of 10 to 20 by swelling in water. The water-binding capacity of psyllium seed shells is even higher, and they can swell up to 40 times (1).
 
Psyllium for the regulation of intestinal activity
The swelling ability of psyllium makes the stool softer and more voluminous. The increase in volume stimulates  peristalsis by exerting pressure on the intestinal wall and thus regulates the emptying of the intestines.
In the case of diarrhea,  transit time is extended by the binding of water – helping to alleviate symptoms. The use of psyllium seeds is considered helpful for habitual constipation, diarrhea and irritable colon (2). Comparative studies have also shown that psyllium seeds have a significantly better effect on irritable colon than wheat bran. Psyllium is therefore superior to bran preparations in therapeutic use as a source of fiber (3).
 
The direct effect of fibers on constipation and hemorrhoids
In industrial nations, up to a quarter of the population is affected by chronic constipation. Lack of exercise, low fluid intake and a fiber intake far below the recommended reference values are the main causes of constipation (4). An increase in fiber intake is considered a promising therapeutic measure (5). The increased stool volume and the resulting mechanical stretching stimulates intestinal peristalsis, shortens the transit time of the stool and facilitates bowel emptying. The increased stool volume and the softer consistency are particularly indicated for patients with hemorrhoidal changes and after hemorrhoidectomies. Reduced pain, faster healing and an average shorter postoperative stay in hospital are confirmed by clinical data (6). The activity of dietary fibers is supported by magnesium citrate, which also counteracts constipation (7).
 
Fiber in hypercholesterolemia and diabetes
An increase in fiber intake influences the glycemic response. Dietary fibers can lead to a slower increase in blood sugar levels and a more even release of insulin. This can improve glucose tolerance in both healthy people and type 2 diabetics (2). The intake of psyllium in clinical studies led to controlled glucose homeostasis and a more optimized lipid profile (8). The cholesterol-lowering effects of psyllium are attributed to the binding and excretion of bile acids in the intestine. As a result, new bile acids must be synthesized. A cholesterol is required for bile synthesis, this leads to a drop in serum cholesterol levels (9). In addition, dietary fibers bind triglycerides, fatty acids and cholesterol from food and thus help to regulate blood fats (10). This significantly reduces the risk of cardiovascular disease (9).
 
Hunger and appetite control for overweight and obesity
Fibers begin to swell in the stomach, increasing the volume and resulting in a long-lasting satiation effect that delays the onset of new feelings of hunger. The modulated release of insulin also leads to lower appetite and hunger signals at the metabolic level.
 
Protective effects in colon and rectal cancer
A high dietary fiber intake reduces the risk of malignant tumors of the colon. Faster excretion of potentially carcinogenic noxae reduces their contact with epithelial cells. Increased synthesis of protective short-chain fatty acids by intestinal bacteria, also contributes to the reduction of tumor risk through inhibition of cell proliferation and inducement of apoptosis (2). By strengthening the intestinal flora with the help of pre- and probiotics, a modulated immune response can possibly also prevent the development of cancer in other tissues (11) (12).
 

Indications

Effect Indication Dosage
Physiological effects
at a low intake
To activate intestinal function in obstipation and constipation as well as in irregular and difficult defecation 2 - 4 g psyllium husks/d 
In case of reduced intestinal motility due to bed rest 2 - 4 g psyllium husks/d  
For more comfortable defecation in anal fissures, hemorrhoids and after hemorrhoidectomy 2 - 4 g psyllium husks/d  
Complementary therapy for irritable bowel and non-specific diarrhea 2 - 4 g psyllium husks/d  
Complementary therapy for obesity, diabetes mellitus and hyperlipidemia as well as Morbus Crohn 2 - 4 g psyllium husks/d  
For hunger and appetite control by improved satiation 2 - 4 g psyllium husks/d  
For cleansing and detoxification of the intestine as well as to build up a healthy intestinal flora 2 - 4 g psyllium husks/d  

Administration

General mode of administration
 
When
 
Psyllium should be taken 30 - 50 minutes before a meal.
Side effects
Adequate fluid intake must be ensured, otherwise constipation may occur. Occasionally mild gastrointestinal complaints (flatulence) may occur. For sensitive persons a gradual increase in dosage is recommended.
 
Contraindications
Do not use in case of colon diverticulosis/diverticulitis, as the storage and swelling of the psyllium in the diverticula can lead to flatulence and abdominal pain.
 

Interactions

Drug interactions
 None No relevant interactions are known to date.
Nutrient interactions
Minerals and vitamins Fiber can reduce the bioavailability of minerals and vitamins. Supplementation with micronutrients should always be at a seperate time to fiber supplementation.

References

References

1) Yu, L. L. et al. 2009. Beneficial health properties of psyllium and approaches to improve its functionalities. Adv Food Nutr Res. 55:193-220.

2) Singh, B. 2007. Psyllium as therapeutic and drug delivery agent. Int J Pharm. 334(1-2):1-14.

3) Bijkerk, C. J. et al. 2009. Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 339:b3154.

4) Krammer, H. 2005. Therapeutic options of chronic constipation. Internist. 46(12): 1331-8.

5) Anderson, J. W. et al. 2009. Health benefits of dietary fiber. Nutr Rev. 67(4):188-205.

6) Kecmanovic, D. et al. 2006. Bulk agent Plantago ovata after Milligan-Morgan hemorrhoidectomy with Ligasure. Phytother Res. 20(8):655-8.

7) Guerrera, M. P. et al. 2009. Therapeutic uses of magnesium. Am Fam Physician. 80(2):157-62.

8) Moreno, L. A. et al. 2003. Psyllium fibre and the metabolic control of obese children and adolescents. J Physiol Biochem. 59(3):235-42.

9) Theuwissen, E., Mensink, R. P. 2008. Water-soluble dietary fibers and cardiovascular disease. Physiol Behav. 94(2):285-92.

10) Allen, K. G., Bristow, S. J. et al. 2004. Hypolipidemic effects of modified psyllium preparations. J Agri Food Chem. 52(16)4998-5003.

11) Davis, C. D., Milner, J. A. 2009. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem. 20(10):743-52.

12) Kumar, M. et al. 2010. Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr.

References Interactions:
Stargrove, M. B. et al. Herb, Nutrient and Drug Interactions: Clinical Implications and Therapeutic Strategies, 1. Auflage. St. Louis, Missouri: Elsevier Health Sciences, 2008.

Gröber, U. Mikronährstoffe: Metabolic Tuning –Prävention –Therapie, 3. Auflage. Stuttgart: WVG Wissenschaftliche Verlagsgesellschaft Stuttgart, 2011.

Gröber, U. Arzneimittel und Mikronährstoffe: Medikationsorientierte Supplementierung, 3. aktualisierte und erweiterte Auflage. Stuttgart: WVG Wissenschaftliche Verlagsgesellschaft Stuttgart, 2014.
 

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