Active substances and pharmaceuticals concerned
| Name of active substance | Trade name | Affected micronutrients |
| Antibiotics | Probiotics Zinc |
| Name of active substance | Trade name | Affected micronutrients |
| Antibiotics | Probiotics Zinc |
| Mechanism of interaction | |
| Probiotics | Colonization of the intestine by pathogenic germs in theintestine can be reduced or prevented by the administration of probiotics. |
| Zinc | The administration of zinc improves humoral and cellular immune competence. |
| Positive consequences of the interaction | Possible symptoms | |
| Probiotics | Intestinal protection | Duration and severity of antibiotic-associated diarrhea are improved. |
| Zinc | Improvement of antibiotic therapy | Frequency of infections is minimized. |
| Medical substance | Recommended supplementation | Dosage |
| Antibiotics | Zinc | 0,5 mg/kg BW/d p.o. |
| Name of active substance | Instructions for use | |
| Antibiotics | Probiotics Zinc |
An interval of two to three hours from antibiotic intake is strongly recommended before ingestion. |
| References |
| Brooks WA et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet. 2004 May 22;363(9422):1683-8. D'Souza AL et al. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002 Jun 8;324(7350):1361. Gröber U. Mikronährstoffe. Metabolic Tuning – Prävention – Therapie. 3. Auflage, 2011 Gröber U. Arzneimittel und Mikronährstoffe. Medikationsorientierte Supplementierung. 3. Akt. und erw. Auflage, 2014 Qasemzadeh MJ et al. The effect of adjuvant zinc therapy on recovery from pneumonia in hospitalized children: a double-blind randomized controlled trial. Scientifica (Cairo). 2014;2014:694193. doi: 10.1155/2014/694193. Epub 2014 May 12. Stargrove Mitchell Bebel, Treasure Jonathan, McKee Dwight L.: Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. 2008 |