Miracon Science

Parkinson's disease remedies

Mechanism of interaction

Mechanism of interaction
Vitamin B6 Conversion of L-dopa to dopamine in the periphery is accelerated. This leads to an induction of L-dopa-carboxylase by the coenzyme pyridoxal phosphate.
Niacin The decarboxylase inhibitors inhibit kynurenine hydroxylase, resulting in a reduction in peripheral synthesis of nicotinamide coenzyme from L-tryptophan. In addition, carbidopa is capable of binding pyridoxal phosphate to initiate inhibition of pyridoxal phosphokinase and tryptophan metabolism disorder.
Vitamin C Simultaneous administration improves the oral bioavailability of L-dopa.
Iron Iron and L-dopa and/or entacapone form a complex in the gastrointestinal tract. There is a reduced resorption of the drug.
Coenzyme Q10 The need for coenzyme Q10 can be increased by the administration of L-dopa, since reactive oxygen species are always produced during synthesis, release, reuptake and enzymatic degradation of neurotransmitters.

Consequences and possible symptoms of the interaction

Negative consequences of the interaction Possible symptoms
Vitamin B6 Loss of efficacy of the drug
  • Decrease in oral bioavailability
  • Parkinson's symptoms  increase, cardiovascular and gastrointestinal disorders increase
Niacin Decrease in niacin levels
  • Exhaustion, memory problems, muscle weakness, sleep problems
  • Encephalopathies (tremor, rigor, spastic paresis)
  • Susceptibility to infection
  • Glossitis, corner of the mouth rhagades, inflammation of the esophagus and GIT
  • Cracked, flaky skin, strong pigmentation, increased cornification, pellagra (dermatitis, diarrhea, dementia)
Iron Complexing
  • Reduced absorption and lower bioavailability of drug
Coenzyme Q10 Decrease of coenzyme Q10 levels
  • Fatigue, weakness
  • Muscle weakness and pain
  • Disorders of cardiac bioenergetics, endothelial dysfunctions
  • Increased risk of Alzheimer's disease, tumors, Parkinson's disease
  • Increased laboratory parameters for nitrosative stress
Positive consequences of the interaction Possible symptoms
Vitamin C Resorption increase
  • Increase of L-dopa in the organism and maximum plasma concentration
  • Oral bioavailability increases

Recommended Supplementation

Medical substance Recommended supplementation Dosage
Carbidopa, Benserazide Niacinamide 200 mg/d p.o.
All Folic acid 0.4-1 mg/d p.o.
Vitamin B12 100-1000 µg/d p.o.
L-dopa Vitamin C 200-500 mg/d p.o.
Coenzyme Q10 5-20 mg/kg BW/d p.o.

Special instructions for use

Instructions for use
Vitamin B6 Do not self-medicate at high doses (5–10 mg/d p.o.) with simultaneous L-dopa intake.
Niacin Parkinson's patients under drug therapy should always be recommended a B-complex, as the drugs also have a negative influence on homocysteine levels.
Iron An interval of two to three hours between iron intake and medication is strongly recommended.
Coenzyme Q10 A combination with antioxidants such as L-glutathione and vitamin E is suggested.
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