Liver protection & liver dysfunction

Micronutrient therapy

 Stimulates liver detoxification
L-glutathione  is significantly involved in the detoxification of toxic metabolic products. Formaldehyde and acetaldehyde, two cytotoxins produced by alcohol, drugs or pesticides in the liver, are neutralized by reduced glutathione. In addition, the synthesis capacity of the liver cells is supported by the intracellular glutathione stock. 
 
Lecithin  intake (> 1 g/day) supporst membrane properties, minimizes the accumulation of fat in the liver and promotes cell regeneration, in the case of acute liver damage. Lecithin also protects the liver tissue against an accumulation of triglycerides and other fats in the cells in alcohol diseases. In addition, lecithin stimulates the enzymatic systems to degrade and excrete toxins and foreign substances. Phospholipids can also have a positive effect on antioxidative processes by improving the glutathione status. 
 
Black cumin seed oil  strengthens the endogenous antioxidant protection systems of the liver. Both the lipid peroxidation of hepatocyte membranes and the oxidation of liver enzymes can be reduced by additional supplementation with black cumin seed oil. As the central detoxification organ, the liver is exposed to a high oxidative load by liver toxins. Black cumins free radical scavenging mechanisms efficiently increase the protective functions. This is particularly important when taking medication. 
 
Alpha-lipoic acid  is not only a universal antioxidant, but is also used for the elimination of heavy metals. The regeneration of L-glutathione also supports the liver in detoxification. 
 Plant extracts to strengthen the liver
Milk thistle extract (Silybum fructus) contains the active complex silymarin, which shows positive effects in clinical studies especially in chronic inflammatory, toxic and alcohol-related liver diseases and liver cirrhosis. Silymarin can prevent the penetration of toxic compounds into hepatocytes by binding to membrane proteins. In addition, the protein synthesis rate and thus the ability of healthy liver cells to regenerate is increased and the repair of cellular-structural damage that has already occurred is promoted. 
 
Artichoke  (Cynara scolymus) increases the metabolic performance of the liver, stimulates cell growth and cell division and protects against many toxic substances through an antioxidant effect. 
 Supplies essential amino acids
The branched-chain amino acids L-leucine, L-valine and L-isoleucine (BCAAs) are mainly metabolized in the skeletal muscles and only to a small extent in the liver and are therefore an important dietary measure for maintaining the protein balance in liver diseases, especially liver cirrhosis. In a damaged liver parenchyma, they represent a less stressful protein source than other amino acids. In addition, substitution with BCAA increases hepatic and extrahepatic ammonia detoxification and can normalize amino acid imbalances and improve psychomotor functions in liver diseases.
 Compensates for micronutrient deficits
Chronic alcohol consumption affects the metabolism of  magnesium  and almost all vitamins, particularly vitamin B6 as alcohol impairs the phosphorylation of pyridoxine to P5P in the liver. Due to the involvement of P5P in neurotransmitter synthesis, there is a direct correlation with neurological deficits in alcoholics. Reduced immune defense could also be explained by insufficient endogenous P5P formation. 

Diagnostic tests

Possible laboratory examination (Laboratory GANZIMMUN) Detail information
Liver profile alk. Phosphatase, bilirubin total,
Blood sugar, cholinesterase, electrophoresis incl. total protein, GST-alpha, GLDH, GOT, GPT, HbA1c, LAP
Liver elevated values – what to do?
alcohol. fatty liver CDT, GPT, uric acid, IgA, triglycerides, magnesium, phosphate, small blood count Liver elevated values – what to do?
Non-alcohol. fatty liver Blood sugar, HbA1c, proinsulin intact,
triglycerides, cholesterol, HDL, LDL
Liver elevated values – what to do?
Biochemistry of Detoxification GST-alpha, GST-theta, glutathione Liver elevated values – what to do?
infectious hepatopathies Hepatitis Screening, Epstein-Barr Virus, CMV  Liver elevated values – what to do?
Autoimmune hepatopathies Autoimmune Screen
AMA, ANA, ANCA, ASMA, LKM, SLA
Liver elevated values – what to do?
other hepatopathies hereditary hemochromatosis, hemochromatosis, Wilson's disease,
coeruloplasmin,
Liver elevated values – what to do?
Analysis of organic acids Sensitive mass spectrometric method for the early diagnosis of an increased colonization of pathogenic microorganisms in the intestine Organix®-Dysbiosis
Coenzyme Q10 To investigate reduced antioxidative capacity and mitochondrial energy supply Coenzyme Q10: cholesterol-corrected coenzyme Q10
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