Miracon Science

taxanes

Active substances and pharmaceuticals concerned

Name of active substance Trade name Affected micronutrients
Paclitaxel Abraxane®, Paclitaxel® L-carnitine

Mechanism of interaction

Mechanism of interaction
L-carnitine Neuropathic side effects are the most common side effects during cytostatic therapy. L-carnitine, as a mitochondrial substrate, can counteract this problem. Its effect is probably due to the increase in the nerve growth factor and the interaction with NF-kappaB.

Consequences and possible symptoms of the interaction

Positive consequences of the interaction Possible symptoms
L-carnitine Side effect reduction
  • Neuropathic complaints are minimized.

 

Recommended Supplementation

Medical substance Recommended supplementation Dosage
Paclitaxel L-carnitine (Acetyl-L-carnitine) 1000-2000 mg/IV

Special instructions for use

Recommended supplementation
L-carnitine WARNING: Do not self-medicate. Use only under medical supervision.

References

References

De Grandis D. Acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy: a short review. CNS Drugs. 2007;21 Suppl 1:39-43; discussion 45-6.
Flatters SJ et al. Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. Neurosci Lett. 2006 Apr 24;397(3):219-23. Epub 2006 Jan 6.
Ghirardi O et al. Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine. In Vivo. 2005 May-Jun;19(3):631-7.
Gröber U. Mikronährstoffe. Metabolic Tuning – Prävention – Therapie. 3. Auflage, 2011
Gröber U. Arzneimittel und Mikronährstoffe. Medikationsorientierte Supplementierung. 3. Akt. und erw. Auflage, 2014
Stargrove Mitchell Bebel, Treasure Jonathan, McKee Dwight L.: Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. 2008

 

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