Miracon Science

thyroid hormone

Active substances and pharmaceuticals concerned

Name of active substance Trade name Affected micronutrients
L-Thyroxin Euthyrox®, Thyrex® Selenium
Iron
Calcium

Mechanism of interaction

Mechanism of interaction
Selenium Selenium, as cofactor of glutathione peroxidases and deiodinases, optimizes thyroid hormone metabolism. Additionally, lipid peroxidation is inhibited and TSH levels are reduced.
Iron
Calcium		 When taken simultaneously, complex formation occurs and therefore the effect of the drug is reduced.

 

Consequences and possible symptoms of the interaction

Negative consequences of the interaction Possible symptoms
Iron
Calcium		 Complex formation
  • Diminished bioavailability of the drug
  • Fluctuations in effect of L-thyroxine
Positive consequences of the interaction Possible symptoms
Selenium Effect optimization
  • Lowering of inflammatory processes in thyroid tissue
  • Cytokine production decreases
  • Improvement of clinical symptoms

 

Recommended Supplementation

Medical substance Recommended supplementation Dosage
L-Thyroxin Sodium Selenite 200-300 µg/d p.o.

Special instructions for use

Instructions for use
Iron
Calcium		 A minimum interval of one to two hours between drug and supplement intake is recommended.

 

References

References

A Irving S et al. Drugs that interact with levothyroxine: an observational study from the Thyroid Epidemiology, Audit and Research Study (TEARS). Clin Endocrinol (Oxf). 2014 Jul 17. doi: 10.1111/cen.12559.
Gröber U. Mikronährstoffe. Metabolic Tuning – Prävention – Therapie. 3. Auflage, 2011
Gröber U. Arzneimittel und Mikronährstoffe. Medikationsorientierte Supplementierung. 3. Akt. und erw. Auflage, 2014
Köhrle J. Seleniumium and the thyroid. Curr Opin Endocrinol Diabetes Obes. 2013 Oct;20(5):441-8. doi: 10.1097/01.med.0000433066.24541.88.
Onal H et al. Effects of Seleniumium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study. J Pediatr Endocrinol Metab. 2012;25(7-8):639-44.
Stargrove Mitchell Bebel, Treasure Jonathan, McKee Dwight L.: Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. 2008

 

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